Properties / Benefits:

❖ Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2

❖ MW = 711.85296 g/mol

❖ GHRP; third generation

❖ Increases GH release per somatotrope

❖ Selective agonist for ghrelin

❖ Stable form

❖ Suppresses somatostatin

❖ Doesn’t raise cortisol, aldosterone, or prolactin levels

❖ At very large doses, was reported to give a large release of GH without desensitization

❖ Doesn’t promote hunger

❖ Doesn’t have ghrelin’s lipogenic effects

❖ 2-hour half-life

❖ Increases bone growth

❖ Improves GI recovery after bowel resection and it is a treatment for postoperative ileus

Clinical Pearls:

❖ When injecting: after the jab, introduce the medication very slowly; It is received by the pituitary gland very quickly activating it; this helps to reduce facial flushing, feeling warm, and tachycardia (rare, usually short-lived 5 minutes), injection site pruritus.

❖ If a patient is sensitive to injection site pruritus, avoid the abdominal fat and instruct them to inject it into the outer gluteal fat (which seems to be less sensitive there).

Dosage:

❖ Some recommend 100 mcg or 1 mg/kg (and believe there is a saturation dose)

➢ Industry standards however are quite different

➢ Can be dosed alone or w/GHRHs

❖ Advitam Protocol- Cre8 Pharmacy:

➢ 9 mg vial

➢ Reconstitute w/ 4.5mL Bacteriostatic Water

➢ Roll between hands for 30 seconds and then refrigerate the mixture when not in use

➢ Inject 20 units (400mcg) subcutaneously (belly fat or gluteus fat) at bedtime, at least 90 minutes after the last meal

➢ 5 days on, 2 days off

Possible side effects:

❖ Injection site erythema

❖ Injection site pruritus

❖ Peripheral edema

Ipamorelin (GHRP)