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EPITHALON (EPITHALON ACETATE
TETRA-PEPTIDE)

Description: (William Seeds, MD)

Epithalon (also known as Epitalon or Epithalone) is a synthetic version of the polypeptide epithalamion, which is naturally produced in humans in the epithalamium-epiphyseal region of the brain. Epithalamion increases a person’s resistance to emotional stress and also acts as an antioxidant. It is a bioregulator for the endocrine system, especially for the pineal gland, and has been shown to lengthen telomeres in human cells. It reduces lipid oxidation ROS (reactive oxygen species) and normalizes T cell function, which assists with cell repair. It also demonstrates the ability to restore and normalize melatonin levels in older people who have lost some pineal function due to aging.

Properties:
❖ MM = 390.34588 g/mol
❖ Sequence: Alanine-Glutamate-Asparagine-Glycine
❖ Anti-aging
❖ Regulates cell cycle through telomerase activity upregulation

Benefits:
❖ Decelerates aging
❖ Suppresses tumor development
❖ Induces telomerase activity
❖ Induces telomere elongation
❖ Prevents chromosome fusion
❖ Decreases incidence of spontaneous radiation in carcinogenic tumors
❖ Normalizes reproductive system in senescent animals
❖ Improves antioxidant defense
❖ Normalizes melatonin levels
❖ Improves cortisol secretion consistent with circadian rhythms
❖ Improves insulin sensitivity

Clinical Pearls:
❖ Can be used as a starting therapy to help with DNA repair and upregulate antioxidants
❖ Can be given as a stand-alone therapy twice a year as it is valuable for cell protection, improving cell resistance, and stopping cell senescence from occurring
❖ Can be used intermittently with other peptide therapies

Dosage:
❖ IM injection
➢ 100 mg total; 10 mg IM qd x 10 days every year x 2 years
➢ 50 mg total (Ukraine Academy Medical Sciences); 10 mg IM every 3rd day, every 6 months x 3 years
❖ Troches
➢ 3 mg sublingual x 30 d (minimum 2-month break in between cycles)

Possible side effects:
❖ Injection site erythema
❖ Injection site pruritus
❖ Peripheral edema