Description: (William Seeds, MD)

Epithalon (also known as Epitalon or Epithalone) is a synthetic version of the polypeptide epithalamion, which is naturally produced in humans in the epithalamium-epiphyseal region of the brain. Epithalamion increases a person’s resistance to emotional stress and also acts as an antioxidant. It is a bioregulator for the endocrine system, especially for the pineal gland, and has been shown to lengthen telomeres in human cells. It reduces lipid oxidation ROS (reactive oxygen species) and normalizes T cell function, which assists with cell repair. It also demonstrates the ability to restore and normalize melatonin levels in older people who have lost some pineal function due to aging.

❖ MM = 390.34588 g/mol
❖ Sequence: Alanine-Glutamate-Asparagine-Glycine
❖ Anti-aging
❖ Regulates cell cycle through telomerase activity upregulation

❖ Decelerates aging
❖ Suppresses tumor development
❖ Induces telomerase activity
❖ Induces telomere elongation
❖ Prevents chromosome fusion
❖ Decreases incidence of spontaneous radiation in carcinogenic tumors
❖ Normalizes reproductive system in senescent animals
❖ Improves antioxidant defense
❖ Normalizes melatonin levels
❖ Improves cortisol secretion consistent with circadian rhythms
❖ Improves insulin sensitivity

Clinical Pearls:
❖ Can be used as a starting therapy to help with DNA repair and upregulate antioxidants
❖ Can be given as a stand-alone therapy twice a year as it is valuable for cell protection, improving cell resistance, and stopping cell senescence from occurring
❖ Can be used intermittently with other peptide therapies

❖ IM injection
➢ 100 mg total; 10 mg IM qd x 10 days every year x 2 years
➢ 50 mg total (Ukraine Academy Medical Sciences); 10 mg IM every 3rd day, every 6 months x 3 years
❖ Troches
➢ 3 mg sublingual x 30 d (minimum 2-month break in between cycles)

Possible side effects:
❖ Injection site erythema
❖ Injection site pruritus
❖ Peripheral edema